3-Hydroxy-N-methyl-L-tyrosine → alpha-Glucose methyldopa

HRID 2256803Notes

Reaction equation

HRID 2256803 reaction equation
[C@H:1]1([N:12](C)[C@@H:13]([CH2:17][C:18]2[CH:25]=[C:23]([OH:24])[C:21]([OH:22])=[CH:20][CH:19]=2)[C:14]([OH:16])=[O:15])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3].CN[C@@H](CC1C=C(O)C(O)=CC=1)C(O)=[O:31]>>[CH3:1][NH:12][C@@H:13]([CH2:17][C:18]1[CH:25]=[C:23]([OH:24])[C:21]([OH:22])=[CH:20][CH:19]=1)[C:14]([OH:16])=[O:15].[OH:31][C@H:1]1[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3]

Participants

3

Reactant 2

HCID 236208563-Hydroxy-N-methyl-L-tyrosineHCID 131720109alpha-Glucosyl methyldopa2×

Product 1

HCID 131720108alpha-Glucose methyldopa

Procedure

A fraction containing α-glucosyl methyldopa was recovered, concentrated in vacuo and pulverized to obtain a white α-glucosyl methyldopa preparation in the yield of about 55% against the weight of the material methyldopa, d.s.b. High-performance liquid chromatography (HPLC) analysis of the preparation revealed that it contained about 60% 3-α-glucosyl methyldopa and about 40% 4-α-glucosyl methyldopa.

Workup

  1. customwas recovered
  2. concentrationconcentrated in vacuo
  3. customto obtain

Sources & evidence

ORD record
ord-1247b2c0cb8d43d192fd69a687cc6ef5
Source dataset
uspto-grants-1997_08
Patent number
US05656460

Reaction notes

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