HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225685Generated: October 30, 2026
Formamide → 5-Fluoroisoindoline-1,3-dione
https://huagongshe.com/reaction/225685
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 1,3-Isobenzofurandione, 5-fluoro- | HCID 67572 | — |
| Product | 5-Fluoroisoindoline-1,3-dione | HCID 10899038 | 100% |
Reaction Steps
A mixture of 144 mmol 4-fluorophthalic anhydride and 1.16 mol formamide was heated at 200° C. for 2 h. The reaction mixture was poured onto ice-water and the resulting crystals collected by filtration and dried in vacuo to afford the title compound as a yellow solid (100% yield). MS (m/e): 164.4 ([M−H]−, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07557114B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-4d1aa1d4c0e743ae80a7cbddc416b708 |
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| Source note | uspto-grants-2009_07 |
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