Sodium Hydroxide → HCID 54245881, compound

Participants

Reaction Steps

A mixture of ethyl 2-chloro4-(1, 1-dimethylethylsulphonyl)benzoate (7.66 g) and sodium hydroxide (6.09 g) in water was stirred and heated at reflux for 2 hours. It was cooled, diluted with water and acidified to pH1. It was extracted with ethyl acetate, washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give 2-chloro-4-(1,1-dimethylethylsulphonyl)benzoic acid (5.67 g) as an off white solid mp 155.2°-156.8° C.

Provenance & Evidence