1,1,1-Trifluoro-2-propanol → 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

HRID 225696Notes

Reaction equation

HRID 225696 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:15][C:16]([F:21])([F:20])[CH:17]([OH:19])[CH3:18]>>[CH3:14][S:11]([C:8]1[CH:9]=[CH:10][C:2]([O:19][CH:17]([CH3:18])[C:16]([F:21])([F:20])[F:15])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

Product 1

HCID 211003065-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

Procedure

Prepared in analogy to Example B1(b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example B1(a)) and rac-1,1,1-trifluoro-propan-2-ol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 311.3 ([M−H]−, 100%).

Workup

  1. customThe crude material was purified by preparative HPLC

Sources & evidence

ORD record
ord-31c63d1185e945aaa72d14f097c6d08b
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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