HCID 53709988, compound → HCID 54382277, compound

Participants

Reaction Steps

Pyridinium chlorochromate (27.6 g) was suspended in dichloromethane and ethyl 4-chloro-2-fluoro-3-(1-hydroxyethyl)benzoate (14.1 g) was added. The mixture was stirred at room temperature for 2 hours and then heated at reflux for 2 hours. After cooling the solvent was evaporated and the residue purified by column chromatography eluted with a mixture of ethyl acetate and n-hexane (1:5) to give ethyl 4-chloro-3-acetyl-2-fluorobenzoate as a yellow oil (13 g), NMR (CDCl3) 1.3(t,3H), 2.5(s,3H), 4.3(q,2H), 7.1(d,1H), 7.8(t,1H).

Provenance & Evidence