HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → (1,2,3,4-Tetrahydro-isoquinolin-1-YL)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 21830900 | HCID 21830900 | — |
| Solvent | Water | HCID 962 | — |
| Product | (1,2,3,4-Tetrahydro-isoquinolin-1-YL)-acetic acid ethyl ester | HCID 336560 | 97% |
Reaction Steps
Ethyl 1,2,3,4-tetrahydro-2-isoquinolinylacetate-hydrochloride (3.63 g) was dissolved in water (100 mL), treated with NaHCO3 and then extracted with ether (3×75 mL). The combined organic layers were dried over MgSO4, filtered and stripped to afford 3.02 g of ethyl 1,2,3,4-tetrahydro-2-isoquinolinylacetate as a pale yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656629 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-412b14acbad8430c86cd2e70c0167221 |
| Source note | uspto-grants-1997_08 |