Water → HCID 178437889, compound

Participants

Reaction Steps

To a mixture of 1-cyclopentyl-3-ethyl-6-(hydroxymethyl)pyrazolo[3,4-d]pyrimidin-4-one (1.0 g, 3.8 mmol), CH2Cl2 (25 mL) and triethylamine (0.77 g, 7.6 mmol) at -50° C. was added methanesulfonyl chloride (0.44 g, 3.8 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred for 1 hour, CH2Cl2 and water were added and the organic layer was separated, dried over MgSO4, filtered and concentrated in vacuo to afford 1.28 g of crude product. The crude product was combined with that from a similar experimental run and the mixture was recrystallized from ether (2×) to afford 1-cyclopentyl-3-ethyl-6-(methylsulfonyloxymethyl)pyrazolo[3,4-d]pyrimidin-4-one, m.p. 138°-140° C.

Provenance & Evidence