反应详情

温度

70 °C

A solution of 2-trifluoromethoxy benzoic acid [1979-29-9](1.0 g) was added in small batches to chlorosulfonic acid (3.2 mL) at 0° C. After completion of the addition, the reaction mixture was stirred at 70° C. for 4 hours then left at room temperature overnight and heated at 75° C. for another 3 hours. After such time the reaction was slowly poured onto ice, and the precipitate was then filtered, washed with water and dried to yield the title compound as a white solid (1.2 g). MS (m/e): 303.3 (M-H, 100%).

1. additionAfter completion of the addition
2. waitthen left at room temperature overnight
3. temperatureheated at 75° C. for another 3 hours
4. additionAfter such time the reaction was slowly poured onto ice
5. filtrationthe precipitate was then filtered
6. washwashed with water
7. customdried