Sodium methanethiolate → HCID 21979919, compound

HRID 2257197Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](Br)=[CH:5][N:6]=[CH:7]2.[CH3:13][S-:14].[Na+]>>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]([S:14][CH3:13])=[CH:5][N:6]=[CH:7]2

Participants

Reactant 2

HCID 4378561Sodium methanethiolate

HCID 145800574-Bromoisoquinolin-5-amine

Product 1

HCID 21979919HCID 21979919, compound

Procedure

5-Amino-4-bromoisoquinoline (prepared according to the process described by Gordon et al., J. Het. Chem., 4, 410 (1967 ) ) was allowed to react with sodium thiomethoxide according to the procedure of Massie, Iowa State Coll. J. Sci., 21, 41 (1946) (Ca. 41: 3044 g) to give 5-amino-4-methylthioisoquinoline. This material was coupled with 2-hexylthiodecanoic acid (prepared by the procedures described in Examples 1 and 3) using the procedure described in Example 25 to give the title compound.

Sources & evidence

ORD record: ord-cd6c903104a64e4bacedb2ad085e5b1c
Source dataset: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05656634

Reaction notes

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