(+-)-2-Butanol → 2-[(1R)-1-Methylpropoxy]-5-(methylsulfonyl)benzoic acid

HRID 225726Notes

Reaction equation

HRID 225726 reaction equation
F[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:15][CH2:16][CH:17]([OH:19])[CH3:18]>>[C@H:17]([O:19][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])([CH2:16][CH3:15])[CH3:18]

Participants

3

Reactant 2

HCID 6568(+-)-2-ButanolHCID 224675662-Fluoro-5-methanesulfonyl-benzoic acid

Product 1

HCID 588633572-[(1R)-1-Methylpropoxy]-5-(methylsulfonyl)benzoic acid

Procedure

Prepared in analogy to Example B4(c) from 2-Fluoro-5-methanesulfonyl-benzoic acid (example B4(b)) and R-(−)-2-butanol. White solid. MS (m/e): 271.1 ([M−H], 100%).

Sources & evidence

ORD record
ord-fcb62485fbf64e3a8625ade36ff0b332
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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