HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-oxoindan-1-carbonyl chloride → 4-Methyl 1-(5-methyl-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-oxoindan-1-carbonyl chloride | HCID 15730148 | — |
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-Methyl 1-(5-methyl-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915025 | 57.4% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 1.0 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 2.1 ml of triethylamine and 0.75 g of 5-methyl-3-oxoindan-1-carbonyl chloride, to afford 0.84 g of the title compound, melting at 220°-223° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656758 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-fbe478ba7db74da6a69e227c347b0641 |
| Source note | uspto-grants-1997_08 |