HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-1-ylmethyl)morpholine → 4-(3-Oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-1-ylmethyl)morpholine | HCID 18915061 | — |
| Reactant | 3-Oxoindan-1-carbonyl chloride | HCID 21820519 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(3-Oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride | HCID 18915159 | 21% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.86 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 1.96 ml of triethylamine and 0.89 g of 3-oxoindan-1-carbonyl chloride, to afford 0.35 g of the title compound, melting at 260°-265° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656758 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-de4942c9bf7b435986ac8ffc4a65e247 |
| Source note | uspto-grants-1997_08 |