HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dichloro-3-oxoindan-1-carbonyl chloride → 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dichloro-3-oxoindan-1-carbonyl chloride | HCID 15132407 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)thiomorpholine | HCID 15730147 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride | HCID 18915171 | 45.7% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.6 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 0.6 g of triethylamine and 1.0 g of 5,6-dichloro-3-oxoindan-1-carbonyl chloride, to afford 0.39 g of the title compound, melting at 215°-223° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656758 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-548ed1e451b3492f85e10cd3d4bd2c37 |
| Source note | uspto-grants-1997_08 |