HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-1-ylmethyl)thiomorpholine → 4-(5-Methyl-3-oxoindan-1-carbonyl) 3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-1-ylmethyl)thiomorpholine | HCID 15730147 | — |
| Reactant | 5-Methyl-3-oxoindan-1-carbonyl chloride | HCID 15730148 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(5-Methyl-3-oxoindan-1-carbonyl) 3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride | HCID 18915135 | 69.2% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.92 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 1.64 ml of triethylamine and 1.66 g of 5-methyl-3-oxoindan-1-carbonyl chloride, to afford 1.35 g of the title compound, melting at 232°-234° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656758 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-23ca3cad8ab84e1c836026020ddf0b30 |
| Source note | uspto-grants-1997_08 |