HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-1-ylmethyl)thiomorpholine → 4-(6-Methoxy-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-1-ylmethyl)thiomorpholine | HCID 15730147 | — |
| Reactant | 6-Methoxy3-oxoindan-1-carbonyl chloride | HCID 18915069 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(6-Methoxy-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride | HCID 18915033 | 42.1% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.97 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 1.39 ml of triethylamine and 1.23 g of 6-methoxy-3-oxoindan-1-carbonyl chloride, to afford 0.9 g of the title compound, melting at 225°-233° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05656758 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-968e0d4781df4ce4993cf2ea810f61e7 |
| Source note | uspto-grants-1997_08 |