関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclohexanone, 2-hydroxy- | HCID 10785 | — |
| 反応物 | Benzamidine, hydrochloride | HCID 80289 | — |
| 溶媒 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 2-phenyl-4,5,6,7-tetrahydro-1H-benzimidazole | HCID 3852296 | 37.6% |
反応手順
To a solution of 6.3 g benzamidine hydrochloride in 60 mL ammonium hydroxide was added 4.6 g 2-hydroxycyclohexanone. The reaction mixture was heated to 90° C. for 7 hours in a sealed tube. On cooling to room temperature the crystals formed were collected by filtration and after drying yielded 3.0 g 2-phenyl-4,5,6,7,-tetrahydrobenzimidazole (Compound 136), m.p. 300°-301° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05656762 |
|---|
| 出典データセット | uspto-grants-1997_08 |
|---|
| ORD ID | ord-8202884829d746a4941426329021824f |
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| 出典メモ | uspto-grants-1997_08 |
|---|
