1H-Isoindole, 2,3-dihydro-5-iodo-6-(trifluoromethyl)- → (5-Iodo-6-trifluoromethyl-1,3-dihydro-isoindol-2-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	1H-Isoindole, 2,3-dihydro-5-iodo-6-(trifluoromethyl)-	HCID 57753446	—
Reactant	(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid	HCID 58863351	—
Product	(5-Iodo-6-trifluoromethyl-1,3-dihydro-isoindol-2-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone	HCID 57753606	—

Reaction Steps

Prepared in analogy to Example 1 from 5-Iodo-6-trifluoromethyl-2,3-dihydro-1H-isoindole and 5-Methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example B3). Yellow foam. MS (m/e): 607.0 (M+, 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07557114B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-b6f3834ce3764b48ab4d1a1b702d5f75
Source note	uspto-grants-2009_07