2-(4-Aminomethylphenyl)-4-phenyl-5-(4-pyridyl)-imidazole → 2-(4-Biotinamidomethylphenyl)-1-methyl-4-phenyl-5-(4-pyridyl)-imidazole

Participants

Role	Name	HCID	Charge
Reactant	2-(4-Aminomethylphenyl)-4-phenyl-5-(4-pyridyl)-imidazole	HCID 18771539	—
Reactant	n-Hydroxysuccinimide biotin	HCID 86743017	—
Solvent	Dimethylformamide	HCID 6228	—
Product	2-(4-Biotinamidomethylphenyl)-1-methyl-4-phenyl-5-(4-pyridyl)-imidazole	HCID 131720117	—

Reaction Steps

To a solution containing 2-(4-Aminomethylphenyl)-4-phenyl-5-(4-pyridyl)-imidazole (1 equivalent) in DMF was added N-hydroxysuccinimide biotin (1.2 eq). Following normal workup and chromatography the title compound was obtained: CIMS (NH3, m/z): 523 (M+ +H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05656644
Source dataset	uspto-grants-1997_08
ORD ID	ord-9038c7caf7b6455c81c2136227631c4c
Source note	uspto-grants-1997_08