HCID 22922859, compound → HCID 22922852, compound

Participants

Reaction Steps

In the same manner as in the first step of Example 2 except that a solution of E-1-heptenylcatecholborane (20 mmol) in tetrahydrofuran (50 ml) was used in place of the solution of E-1-pentenylcatecholborane and 4-(3-hydroxy-3,3-dimethyl-1-propynyl)-2-fluoro-1-bromobenzene (3.9 g, 15 mmol) was used in place of 4-(3-hydroxy-3,3-dimethyl-1-propynyl)-3-fluoro-1-bromobenzene, the reaction was carried out to obtain 4-(3-hydroxy-3,3-dimethyl-1-propynyl)-1-(1-trans-heptenyl)-2-fluorobenzene (3.3 g). Yield: 81%.

Provenance & Evidence