4-Fluorophenylboronic acid → HCID 11656385, compound

HRID 225744Notes

Reaction equation

HRID 225744 reaction equation
Br[C:2]1[CH:3]=[C:4]2[CH2:10][N:9]([C:11]([C:13]3[CH:18]=[C:17]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:16]=[CH:15][C:14]=3[O:23][C@@H:24]([CH3:29])[C:25]([F:28])([F:27])[F:26])=[O:12])[CH2:8][C:5]2=[N:6][CH:7]=1.[F:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[F:30][C:31]1[CH:36]=[CH:35][C:34]([C:2]2[CH:3]=[C:4]3[CH2:10][N:9]([C:11]([C:13]4[CH:18]=[C:17]([S:19]([CH3:22])(=[O:20])=[O:21])[CH:16]=[CH:15][C:14]=4[O:23][C@@H:24]([CH3:29])[C:25]([F:28])([F:26])[F:27])=[O:12])[CH2:8][C:5]3=[N:6][CH:7]=2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 57753259HCID 57753259, compound

Product 1

HCID 11656385HCID 11656385, compound

Procedure

Prepared in analogy to Example 321 from (3-Bromo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone (example 22) and 4-fluorophenyl boronic acid. White solid. MS (m/e): 509.2 [M+H]+, 100%).

Sources & evidence

ORD record
ord-45db73c4960f456cbf68d0ee3bca17c1
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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