Benzoic acid, 2-hydroxy-3-methyl-, methyl ester → HCID 22922977, compound

Participants

Reaction Steps

Pivaloyl chloride is added dropwise at 10°-15° C. to a stirred mixture of methyl 2-hydroxy-3-methylbenzoate and 4-dimethylaminopyridine in 25 ml of dichloromethane. After 2 hours at room temperature, the reaction is quenched with 200 ml of water. The organic layer is washed with 5% sodium bicarbonate, dried on anhydrous sodium sulfate and evaporated in vacuo. The product is purified by flash chromatography on silica gel.

Provenance & Evidence