2-(4-Hydroxyphenyl)-5-octylpyrimidine → HCID 21225385, compound

HRID 2257482Notes

Reaction equation

HRID 2257482 reaction equation
[CH2:1]([C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[N:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:22][C:23]([F:58])([C:54]([F:57])([F:56])[F:55])[C:24]([F:53])([F:52])[C:25]([F:51])([F:50])[C:26]([F:49])([F:48])[C:27]([F:47])([F:46])[O:28][C:29]([F:45])([F:44])[C:30]([F:43])([F:42])[O:31][C:32]([F:41])([F:40])[CH2:33][O:34][CH2:35][CH2:36][CH2:37][CH2:38]Br>>[CH2:1]([C:9]1[CH:14]=[N:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:38][CH2:37][CH2:36][CH2:35][O:34][CH2:33][C:32]([O:31][C:30]([F:42])([F:43])[C:29]([F:44])([F:45])[O:28][C:27]([F:46])([F:47])[C:26]([F:48])([F:49])[C:25]([F:50])([F:51])[C:24]([F:52])([F:53])[C:23]([F:22])([F:58])[C:54]([F:57])([F:55])[F:56])([F:41])[F:40])=[CH:17][CH:16]=2)=[N:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 6040552-(4-Hydroxyphenyl)-5-octylpyrimidineHCID 212252664-(2-(2-(Tridecafluorohexyloxy) tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromobutane

Product 1

HCID 21225385HCID 21225385, compound

Procedure

The title compound was prepared essentially as in Example 1 by combining 5-octyl-2-(4-hydroxyphenyl)pyrimidine (1.03 g, 3.61 mmol) and 4-(2-(2-(tridecafluorohexyloxy) tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromobutane (2.68 g, 4.02 mmol; prepared from 1,4-dibromobutane and 2-(2-(tridecafluorohexyloxy) tetrafluoroethoxy)-2,2-difluoroethanol). The resulting crude product was isolated essentially as described in Example 3 and further purified by recrystallization from cyclohexane/ethyl acetate to yield 1.85 g of purified product.

Workup

  1. customThe resulting crude product was isolated essentially

Sources & evidence

ORD record
ord-6d8a5386423c4935965dea486d14588c
Source dataset
uspto-grants-1997_08
Patent number
US05658491

Reaction notes

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