反应详情

6-iodo-4-chloro-2-trichloromethyl-quinazolin (8.14 g, 20 mmol) was dissolved in ether (anhydrous 200 mL) under stirring at rt. To this solution 3-amino-1-ethyl-piperidine (2.56 g, 20 mmol) in ether (anhydrous 30 mL) was added at 0° C. The reaction mixture was allowed to warm to rt overnight. Buff colored solid separated which was filtered, washed with ether (200 mL) and air dried. Crude yield: 5.1 g. The crude material was suspended in MeOH and stirred vigorously for 0.5 h and filtered. The solid was dried in vacuo (0.01 mm). Yield: 3.72 g, (34.7%). Mp 265°-266° C.

1. temperatureto warm to rt overnight
2. customseparated which
3. filtrationwas filtered
4. washwashed with ether (200 mL) and air
5. customdried
6. stirringstirred vigorously for 0.5 h
7. filtrationfiltered
8. customThe solid was dried in vacuo (0.01 mm)