Hydroxyamine hydrochloride → (2,4-Difluorophenyl)-pyridin-4-yl methanone oxime

Participants

Reaction Steps

62.6 g (0.900 mole) of hydroxylamine hydrochloride and 133.6 g (0.982 mole) of sodium acetate trihydrate were added to a suspension of 179.4 g (0.818 mole) of the compound of Example 1 in 1L of ethanol and the mixture was refluxed for 1 hour. The solvent was removed under low pressure evaporation, 1L of water was added to the residue and it was filtered. After drying for 3 hours at 45° C., 181 g (94% yield) of the title compound (mixture of sin- and anti-isomers) were obtained, as a white solid.

Provenance & Evidence