5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione → HCID 15378693, compound

HRID 2257689Notes

Reaction equation

HRID 2257689 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]2[C:29](=O)[O:28][C:26](=[O:27])[C:25]2=[CH:31][CH:32]=1>ClCCl>[F:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]4[C:29](=[O:28])[C:24]5=[CH:23][C:22]([O:21][CH3:20])=[CH:32][CH:31]=[C:25]5[C:26]4=[O:27])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6397485-Methoxy-1,3-dihydro-2-benzofuran-1,3-dioneHCID 146998572-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethan-1-amine

Product 1

HCID 15378693HCID 15378693, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred mixture of 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethylamine (2.63 g, 0.01 mole) and 4-methoxyphthalic anhydride (1.78 g, 0.01 mole) in dichloromethane (100 ml) is stirred at room temperature for 3 hours. The solvent is then removed under reduced pressure and the residual material is purified by flash chromatography. The product is purified further by recrystallization to give N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-4-methoxyphthalimide.

Workup

  1. customThe solvent is then removed under reduced pressure
  2. customthe residual material is purified by flash chromatography
  3. customThe product is purified further by recrystallization

Sources & evidence

ORD record
ord-a2809be2d67846a58f66fef1249d4d2b
Source dataset
uspto-grants-1997_08
Patent number
US05658911

Reaction notes

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