Pyridine → HCID 22923086, compound

Participants

Reaction Steps

In succession, 0.54 g of 2-amino-4,6-dimethoxypyrimidine and 1.50 g of methyl 2-chlorosulfonyl-3-(N-methoxycarbonylmethylamino)benzoate are added at room temperature to a suspension of 0.61 g of sodium cyanate, 0.8 ml of pyridine and 18 ml of acetonitrile. The reaction mixture is stirred at room temperature for 3.5 h and then poured into ice-water. For purification the sulfonylurea which is separated out is stirred in a little methanol, separated off by means of filtration and dried. The resulting N-[(4,6-dimethoxypyrimidin-2-yl)amino-carbonyl]-2-methoxycarbonyl-6-(N-methoxycarbonylmethylamino)benzenesulfonamide is obtained as a colorless solid (1.35 g) 150°-154° C.

Provenance & Evidence