HRID2257716

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2ncnc(N3CCC(n4c(=O)[nH]c5ccc([N+](=O)[O-])cc5c4=O)CC3)c2cc1OC

HCID22923399

3-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-6-nitro-2,4(1H,3H)-quinazolinedione

C23H22N6O6

结构：COc1cc2ncnc(N3CCC(n4c(=O)[nH]c5ccc(Cl)cc5c4=O)CC3)c2cc1OC

HCID22923543

6-Chloro-3-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-2,4(1H,3H)-quinazolinedione

C23H22ClN5O4

2 次

PRODUCTS

生成物

结构：COc1cc2ncnc(N3CCC(n4c(=O)c5cc(Cl)ccc5n(C)c4=O)CC3)c2cc1OC

HCID22923508

未命名化合物

收率 65%

PROCEDURE

实验过程

The procedure similar to that described in Example 1 was repeated, except that 300 mg (0.64 mmol) of 6-chloro-3-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-2,4-dioxoquinazoline (Compound h) obtained according to the method described in the literature [Chem. Pharm. Bull., 38, 1591-1595 (1990)] was used in place of Compound 24. As a result, 199.2 mg (yield: 65%) of Compound 40 was obtained as white crystals.

WORKUP

后处理

customobtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2abc247168b44d1893d962dd1dbfb27c
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05658917
来源说明: uspto-grants-1997_08

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[N:6]([CH:13]1[CH2:18][CH2:17][N:16]([C:19]3[C:28]4[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]1)[C:5]2=[O:33].[CH3:34]OC1C=C2C(=CC=1OC)N=CN=C2N1CCC(N2C(=O)C3C(=CC=C([N+]([O-])=O)C=3)NC2=O)CC1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:34])[C:7](=[O:12])[N:6]([CH:13]1[CH2:14][CH2:15][N:16]([C:19]3[C:28]4[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][N:20]=3)[CH2:17][CH2:18]1)[C:5]2=[O:33]