HRID2257735

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Br.Cc1ccc2c(c1)c(=O)n(C1CCNCC1)c(=O)n2C

HCID21851222

未命名化合物

2 次

结构：Clc1ncnc2cc(OCc3ccccc3)c(OCc3ccccc3)cc12

HCID22923433

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2c(c1)c(=O)n(C1CCN(c3ncnc4cc(OCc5ccccc5)c(OCc5ccccc5)cc34)CC1)c(=O)n2C

HCID22923488

未命名化合物

收率 54%

PROCEDURE

实验过程

The procedure similar to that described in Example 61 was repeated, except that 836.0 mg (2.36 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)-quinazoline hydrobromide (Compound v) obtained in Example 41 was used and 6,7-dibenzyloxy-4-chloroquinazoline was used in place of 4-chloro-6,7-dimethoxyquinazoline. As a result, 786.3 mg (yield: 54%) of Compound 88 was obtained as white crystals.

WORKUP

后处理

customobtained in Example 41

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f336b532146b469da03be8aa33306814
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05658917
来源说明: uspto-grants-1997_08

反应 SMILES

Br.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[C:6](=[O:14])[N:5]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]1=[O:21].[CH2:22]([O:29][C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][C:39]=1[O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[N:36]=[CH:35][N:34]=[C:33]2Cl)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][C:39]=1[O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[N:36]=[CH:35][N:34]=[C:33]2[N:18]1[CH2:19][CH2:20][CH:15]([N:5]2[C:6](=[O:14])[C:7]3[C:12](=[CH:11][CH:10]=[C:9]([CH3:13])[CH:8]=3)[N:3]([CH3:2])[C:4]2=[O:21])[CH2:16][CH2:17]1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1