Ethyl bromoacetate → HCID 22923401, compound

HRID 2257746Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=3)[N:22]([CH3:32])[C:21]2=[O:33])[CH2:16][CH2:15]1.Br[CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37]>>[CH2:39]([O:38][C:36]([CH2:35][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=3)[N:22]([CH3:32])[C:21]2=[O:33])[CH2:16][CH2:15]1)=[O:37])[CH3:40]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 22923375HCID 22923375, compound

Product 1

HCID 22923401HCID 22923401, compoundYield 54%

Procedure

The procedure similar to that described in Example 1 was repeated, except that 500.0 mg (1.12 mmol) of Compound 90 obtained in Example 80 was used in place of Compound 24 and ethyl bromoacetate was used in place of methyl iodide. As a result, 323.3 mg (yield: 54%) of Compound 94 was obtained as white crystals.

Sources & evidence

ORD record: ord-2c1baa44fdfd46f4b71ed3cea3b25c12
Source dataset: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05658917

Reaction notes

Loading…