HCID 87596239, compound → HCID 87597125, compound

HRID 225782Notes

Reaction equation

C[O:2][C:3](=[O:35])[CH:4]([NH:23][C:24]1[C:27]2([CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:26](=[O:33])[C:25]=1[Cl:34])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1)=[O:16])[CH2:10][CH2:9]2.ClC1C=NC=C(Cl)C=1C(N1C2C(=CC(CC(NC3C4(CCCCC4)C(=O)C=3)C(O)=O)=CC=2)CC1)=O>>[Cl:34][C:25]1[C:26](=[O:33])[C:27]2([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[C:24]=1[NH:23][CH:4]([CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1)=[O:16])[CH2:10][CH2:9]2)[C:3]([OH:35])=[O:2]

Participants

Reactant 2

HCID 87596239HCID 87596239, compound

HCID 87597062HCID 87597062, compound

Product 1

HCID 87597125HCID 87597125, compound

Procedure

The title compound was prepared from the compound of Example 13 in a similar manner to the compound of Example 2 as a white lyophilised powder (99%). δH NMR (d6 DMSO), 8.73 (2H, m), 7.78 (1H, dd, J 4.3 and 1.5 Hz), 7.61 (1H, m), 7.50 (2H, m), 7.18 (1H, s), 7.05 (1H, d, J 8.2 Hz), 4.58 (1H, m), 4.00 (2H, t, J 8.3 Hz), 3.23 (1H, dd, J 14.1 and 4.8 Hz), 3.06 (3H, m), 1.50 (10H, br m); m/z (ES+, 70 eV) 480 (M+H)+.

Sources & evidence

ORD record: ord-331f7924cd434007a3ee1af7569bd275
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557130B2

Reaction notes

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