HCID 21828801, compound → HCID 22449474, compound

HRID 2257864Notes

Reaction equation

HRID 2257864 reaction equation
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]2[C:6]=1[C:7](=[O:16])[CH2:8][CH2:9][S:10]2)(=[O:3])[CH3:2].[C:17]([NH:20]C1C=CC(C)=C2C=1C(=O)CCS2)(=[O:19])[CH3:18]>>[C:17]([NH:20][CH:8]1[C:7](=[O:16])[C:6]2[C:11](=[C:12]([Cl:15])[CH:13]=[CH:14][C:5]=2[NH:4][C:1](=[O:3])[CH3:2])[S:10][CH2:9]1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 21828801HCID 21828801, compoundHCID 22449509HCID 22449509, compound

Product 1

HCID 22449474HCID 22449474, compound

Procedure

The reaction was carried out in the same manner as in Example 12-(1), except that 477 mg of the compound prepared in (1) above was used instead of 5-acetylamino-8-methyl-4-thiochromanone of Example 12-(1). The reaction product was post-treated to produce 171 mg of the title compound. NMR(CDCl3)δ: 2.08(3H, s), 2.20(3H, s), 3.20(1H, d, J=13 Hz), 3.51(1H, dd, J=13.9 Hz), 4.7-4.9(1H, m), 7.50(1H, d, J=9.2 Hz), 8.54(1H, d, J=9.2 Hz)

Workup

  1. additionThe reaction product was post-treated

Sources & evidence

ORD record
ord-ba8fab0e744e45af9475cd028c43d23c
Source dataset
uspto-grants-1997_08
Patent number
US05658920

Reaction notes

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