HCID 67710918, compound → HCID 67710979, compound

HRID 2257895Notes

Reaction equation

HRID 2257895 reaction equation
C(OC([N:11]1[CH2:25][CH:24]([O:26][CH2:27][O:28][CH3:29])[CH2:23][C@H:12]1[C:13]([NH:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:14])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:29][O:28][CH2:27][O:26][CH:24]1[CH2:25][NH:11][C@H:12]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:14])[CH2:23]1

Participants

4

Reactant 1

HCID 67710918HCID 67710918, compound

Product 1

HCID 67710979HCID 67710979, compoundYield 105.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

21.2 g of the obtained N-(1-benzyloxycarbonyl-4-methoxymethoxy-L-prolyl)-N-cyclohexylmethylamine was dissolved in 200 ml of ethanol. To the solution was added 2 g of 10% Pd-C. The mixture was subjected to hydrogenation for 3 hours. The catalyst was removed by filtration. The solvent in the filtrate was removed by distillation to obtain 14.9 g of N-(4-methoxymethoxy-L-prolyl)-N-cyclohexylmethylamine.

Workup

  1. customThe catalyst was removed by filtration
  2. customThe solvent in the filtrate was removed by distillation

Sources & evidence

ORD record
ord-d2dfe7caa3634ca5ac7360780924ef98
Source dataset
uspto-grants-1997_08
Patent number
US05658926

Reaction notes

Loading…