反应详情

A solution of 13.7 g of 6-[3-(N-cyclohexyl-N-methylaminocarbonyl)propoxy]carbostyril and 4.45 g of phosphorus pentasulfide in 200 ml of benzene was refluxed for 5 hours. The reaction mixture was allowed to cool. The insolubles were removed by filtration. The filtrate was subjected to distillation to remove the solvent. The resulting residue was purified by a silica gel column chromatography (eluant: 5% methanol/dichloromethane) to obtain 7.2 g of 6-[3-(N-cyclohexyl-N-methylaminothio-carbonyl)propoxy]carbostyril.

1. temperatureto cool
2. customThe insolubles were removed by filtration
3. distillationThe filtrate was subjected to distillation
4. customto remove the solvent
5. customThe resulting residue was purified by a silica gel column chromatography (eluant: 5% methanol/dichloromethane)