HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (Piperidin-4-yloxy)acetic acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 2-(Piperidin-4-yloxy)acetic acid | HCID 18423627 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Piperidin-4-yloxy)acetic acid methyl ester hydrochloride | HCID 21835549 | — |
Reaction Steps
By esterifying the trifluoroacetate of 4-piperidinyloxy-acetic acid (prepared by treating the product of Example 1c) with trifluoroacetic acid in dichloromethane) in methanol in the presence of thionyl chloride there is obtained methyl 4-piperidinyloxyacetate hydrochloride, MS (EI): 173 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658928 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-bbff8b45f5ae4d93b3165d8c0b688897 |
| Source note | uspto-grants-1997_08 |