N-Carbobenzoxy-L-valine → HCID 54477122, compound

HRID 2257914Notes

Reaction equation

HRID 2257914 reaction equation
[CH3:1][CH:2]([C@H:4]([NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])[C:5]([OH:7])=O)[CH3:3].[NH:19]1[CH2:24][CH2:23][CH:22]([O:25][CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:21][CH2:20]1>>[CH2:12]([O:11][C:9]([NH:8][C@H:4]([C:5]([N:19]1[CH2:20][CH2:21][CH:22]([O:25][CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:24]1)=[O:7])[CH:2]([CH3:1])[CH3:3])=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 726987N-Carbobenzoxy-L-valineHCID 10036224Tert-butyl (piperidin-4-yloxy)-acetate

Product 1

HCID 54477122HCID 54477122, compound

Procedure

By coupling 2.5 g of Z-L-valine with 2 g of t-butyl 4-piperidinyloxyacetate as described in Example 2b) there are obtained 4g of t-butyl [[1-[N-[(benzyloxy)carbonyl]-L-valyl]-4-piperidinyl]oxy]acetate, MS (EI): 449 (M+H)+.

Sources & evidence

ORD record
ord-a0a67df797fb4c2584fe52b0819e9bab
Source dataset
uspto-grants-1997_08
Patent number
US05658928

Reaction notes

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