反应详情

温度

60 °C

Sodium cyanide (1.8 g, 37 mmol) was added to a stirred solution of the intermediate from Step B (10 g, 31 mmol) in DMSO (100 mL). The mixture was heated to 60° C. overnight (˜16 hours) and then the DMSO was removed under reduced pressure. DCM (100 mL) was added to the residue and the resulting mixture was washed with water (1×100 mL), saturated NaCl (1×100 mL), dried over magnesium sulfate, filtered and the solvent removed under reduced pressure to provide 5.4 g of the title intermediate (99% yield), which was used without further purification.

1. customthe DMSO was removed under reduced pressure
2. additionDCM (100 mL) was added to the residue
3. washthe resulting mixture was washed with water (1×100 mL), saturated NaCl (1×100 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customthe solvent removed under reduced pressure