Hydrochloric Acid → HCID 53760924, compound

Participants

Reaction Steps

0.149 mole of 2,3-dimethoxybenzaldehyde is added over 5 hours at room temperature to a solution of 0.149 mole of 1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-ethanone prepared in Example 2.1 in a mixture of 800 ml of ethanol and 186 ml of a 2N aqueous solution of sodium hydroxide. The reaction medium is then brought to pH 7.5 by addition of a 5N aqueous solution of hydrochloric acid. The ethanol is distilled off and a solid is formed, which precipitates. This solid is filtered off and washed with water before drying. The solid is redissolved in 2 liters of boiling 2-propanol and the insoluble salts are filtered off. Half the 2-propanol is evaporated off and the 3-(2,3-dimethoxyphenyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-propen-1-one is recrystallized.

Provenance & Evidence