HCID 22923997, compound → HCID 178490109, compound

Participants

Reaction Steps

17.88 g (0.0687 mole) of 3-(2,3-dimethoxyphenyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-propanone prepared in Example 2.3.a are heated in 100 ml of formic acid for half an hour at 80° C. The reaction medium is then cooled to room temperature and the triphenylmethanol which has precipitated during cooling is filtered off. Formic acid is distilled off and the residue is taken up in water. The aqueous phase is then brought to pH 9 by addition of a 12 mole/l aqueous solution of ammonia. The precipitate which has formed is filtered off and dried and 8.35 g of 3-(2,3-dimethoxyphenyl)-1-(1H-imidazol-4-yl)-1-propanone are obtained.

Provenance & Evidence