HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(1,3-Benzodioxol-5-yl)-4-methoxycyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 8-(Benzo[d][1,3]dioxol-5-yl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 10912840 | — |
| Product | 4-(1,3-Benzodioxol-5-yl)-4-methoxycyclohexanone | HCID 22924043 | 70% |
Reaction Steps
A solution of 8-(1,3-Benzodioxol-5-yl)-1,4-dioxa-spiro[4.5]decan-8-ol (5.0 g, 1.8 mmole) in 100 mL methanol with 1 mL conc. hydrochloric acid was stirred for 22 hr and the solution concentrated in vacuo. The residue was purified by chromatography on silica eluting with ethyl acetate-hexane (1:19) to give the product (70%, mp: 84°-85° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658941 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-34a3e75c6802470f99e929ddf0c9f815 |
| Source note | uspto-grants-1997_08 |