HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 22122104 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone | HCID 22122090 | 62% |
Reaction Steps
A solution of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol (5.4 g, 20 mmole) in acetone-1N hydrochloric acid (1:1) was stirred for 4 hr. The acetone was removed in vacuo and the crude material crystallized from isopropyl ether to give the product (62%, mp: 84°-85° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658941 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-7575572c9c744f8fbd3a4b3280ad4015 |
| Source note | uspto-grants-1997_08 |