Ethylmorpholine → HCID 70095600, compound

Participants

Reaction Steps

10.5 g of 4-[4-(aminoiminomethyl)benzyl]-3,3-bisethoxycarbonylbutyric acid hydrochloride are dissolved in 500 ml of dimethylformamide. 3.75 g of glycine methyl ester hydrochloride, 9.83 g of O-[(cyanoethoxycarbonylmethylene)amino]-N,N,N',N'-tetramethyluronium tetrafluoroborate (TOTU) and 11.5 ml of N-ethylmorpholine are then added successively. The mixture is stirred for 24 h and the solvent is then stripped off in vacuo. The oily residue is chromatographed on silica gel using dichloromethane/methanol/water/acetic acid (100:10:1:1). The fractions containing the product are combined and concentrated.

Provenance & Evidence