HCID 22923955, compound → HCID 22923961, compound

Participants

Reaction Steps

8.75 g of ethyl 4-(4-pyridyl)-3,3-bisethoxycarbonylbutyrate are stirred at 50°-60° C. in 500 ml of 6N HCl for 2 h. The mixture is then concentrated in vacuo and allowed to react again at 50°-60° C. with 500 ml of 6N HCl for 2 h. It is then concentrated to dryness in vacuo and redistilled twice using a little toluene. The residue is taken up in a little water and freeze-dried.

Provenance & Evidence