HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 22923964, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | HCID 22923961 | HCID 22923961 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22923964 | HCID 22923964 | — |
Reaction Steps
9.27 g of 4-(4-pyridyl)-3,3-bisethoxycarbonylbutyric acid are dissolved in 600 ml of dimethylformamide. 3.69 g of glycine methyl ester hydrochloride, 8.78 g of TOTU and 11.5 ml of N-ethylmorpholine are then added successively. The mixture is stirred for 24 h and the solvent is then stripped off in vacuo. The oily residue is chromatographed on silica gel using ethyl acetate. The fractions containing the product are combined and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658935 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-43b13bcef8974925863f72a3c41239af |
| Source note | uspto-grants-1997_08 |