HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylaluminum → N-(2,3-dihydrobenzoxazin-6-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | Ethyl 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylate | HCID 57431514 | — |
| Reactant | 6-Amino-2,3-dihydrobenzoxazine | HCID 66693029 | — |
| Product | N-(2,3-dihydrobenzoxazin-6-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide | HCID 68529616 | 29.2% |
Reaction Steps
The process is performed according to the method described in Example 6, starting with 0.090 g of 6-amino-2,3-dihydrobenzoxazine (WO 2003/049702), 0.5 ml of trimethylaluminum (2M in toluene) and 0.157 g of ethyl 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate, obtained in step 1.1 of Example 1. 0.061 g of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557134B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-67a5489fec274f3fbdac13592286c601 |
| Source note | uspto-grants-2009_07 |