HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylaluminum → N-(3-oxo-2H-benzoxazin-6-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 6-amino-3-oxo-2H-benzoxazine | HCID 22279077 | — |
| Reactant | Ethyl 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylate | HCID 57431514 | — |
| Product | N-(3-oxo-2H-benzoxazin-6-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide | HCID 68534223 | 24.6% |
Reaction Steps
The process is performed according to the method described in Example 6, starting with 0.107 g of 6-amino-3-oxo-2H-benzoxazine (WO 2003/049702), 0.5 ml of trimethylaluminum (2M in toluene) and 0.157 g of ethyl 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate, obtained in step 1.1 of Example 1. 0.053 g of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557134B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-4c3b966fb76344cab04e0f3cb7c773b0 |
| Source note | uspto-grants-2009_07 |