Heptanal → Ethyl 2-[4-(heptylaminoethyl)phenoxy]-2-methylpropionate

Participants

Reaction Steps

The product from step (c) (1.5 g) and heptaldehyde (0.7 g) were mixed together in a observably exothermic reaction and the product dissolved in absolute ethanol (100 ml). Paar hydrogenation for 1.0 hour resulted in a drop in bottle pressure from 49.0 to 42.7 psi. The Pd/C was removed by filtration and the filtrate evaporated in vacuo to give the desired product as a colourless oil (2.1 g).

Provenance & Evidence