Dimethylformamide → HCID 53730614, compound

Participants

Reaction Steps

A solution of 0.40 g (0.65 mmol) of (R,S; R,S)-2- diphenylacetylamino-3-(3-methoxyphenyl)-3-(3-methoxyphenyl-sulfanyl) propionic acid, 2-trimethylsilylethyl ester of Example 34, 3.3 mL of N,N-dimethylformamide and 3.3 mL (3.3 retool) of 1M tetrabutylammonium fluoride in tetrahydrofuran is stirred at room temperature for 30 minutes. Ethyl acetate (100 mL) is added and the solution is washed with 80 mL of 1N hydrochloric acid and 80 mL of brine, dried (magnesium sulfate) and evaporated to give the product; wt 0.31 g (92%). Recrystallization from ethyl acetate-heptane gives product as a 9:1 mixture of diastereomers by NMR and hplc;

Provenance & Evidence