Isopropylamine → HCID 690424, compound

HRID 2258036Notes

Reaction equation

[N+](C1C=C[C:7]([C:8](Cl)=[O:9])=CC=1)([O-])=O.C(N)(C)C.[CH:17]([NH:20][C:21](=[O:31])[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-])=O)=[CH:24][CH:23]=1)([CH3:19])[CH3:18]>>[CH:17]([NH:20][C:21](=[O:31])[C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:8](=[O:9])[CH3:7])=[CH:24][CH:23]=1)([CH3:19])[CH3:18]

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 85024-Nitrobenzoyl chloride

HCID 347926N-Isopropyl-4-nitrobenzamide

Product 1

HCID 690424HCID 690424, compound

Procedure

The method of Example 3 is repeated using 4-nitrobenzoyl chloride and iso-propyl amine in the amidation step. This yields N-iso-propyl-4-nitrobenzamide (CPI1026).

Sources & evidence

ORD record: ord-c232f2b39c4b486daec6169c6a74d261
Source dataset: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05658953

Reaction notes

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