反应详情

A mixture of (E)-N-methyl-2-(1H-indole-5-yl)ethenesulphonamide (2.0 g), 1-methyl-4-piperidone (1.62 g) and potassium hydroxide (0.7 g) in IMS (20 mL) was stirred at ambient temperature for 22 hr. The reaction mixture was concentrated and the residue purified by column chromatography on silica gel. Eluting with dichloromethane/ethanol/ammonia (25:10:1) gave an oil which solidified on standing to a brown solid. Trituration with ether provided the product as a white powder (1.85 g, 64% of theory).

1. concentrationThe reaction mixture was concentrated
2. customthe residue purified by column chromatography on silica gel
3. washEluting with dichloromethane/ethanol/ammonia (25:10:1)
4. customgave an oil which