HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorophenol → 1-Benzyl-4-(3,5-difluorophenoxy)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorophenol | HCID 75928 | — |
| Reactant | 1-Benzylpiperidin-4-ol | HCID 78461 | — |
| Product | 1-Benzyl-4-(3,5-difluorophenoxy)piperidine | HCID 57753829 | — |
Reaction Steps
The title compound was prepared from 1-benzyl-4-hydroxypiperidine and 3,5-difluorophenol, using the same method as that described for preparation 43. The crude compound was purified by column chromatography on silica gel, eluting with dichloromethane:methanol, 95:5, to afford the desired product in 63% yield. LRMS APCI m/z 304 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557131B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-f463fc52d2f34da99e8d72133a5134ba |
| Source note | uspto-grants-2009_07 |